解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Heme oxygenase-1 (HO-1) expression, in response to various stimuli, has been generally reported to protect against cellular stress. However, we previously demonstrated simvastatin-induced HO-1-exaggerated nuclear factor kappa beta (NF-κβ) activation and superoxide production on exposure to lipopolysaccharide (LPS). Th...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480545.2010.482587
更新日期:2011-01-01 00:00:00
abstract::MG132, as a proteasome inhibitor, has been shown to induce apoptotic cell death through the formation of reactive oxygen species (ROS). In this study, we investigated the effects of MG132 and/or MAPK inhibitors on As4.1 juxtaglomerular cells in relation to cell growth, cell death, ROS, and glutathione (GSH) levels. MG...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480540903483458
更新日期:2010-10-01 00:00:00
abstract::Adverse reactions induced by Chinese herbal injections have been frequently reported. However, the precise causes of these adverse reactions are not yet fully understood. The aim of the present study was to determine the role of chlorogenic acid (a ubiquitous component of Chinese herbs) in the toxicity of Chinese herb...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480540903580055
更新日期:2010-10-01 00:00:00
abstract::This study was conducted to evaluate the potential reproductive toxicity of epichlorohydrin in a one-generation reproduction toxicity study in compliance with OECD Test Guideline 415. Twenty-four male and female rats per group were given epichlorohydrin by gavage at 0, 3.3, 10, and 30 mg/kg/day. Males were dosed for 1...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480541003734030
更新日期:2010-07-01 00:00:00
abstract::Oxidative stress is produced under diabetic conditions and is likely involved in the progression of pancreatic damage found in diabetes. This study was undertaken to evaluate the protective effect of Aegle marmelos leaf extract, a medicinal plant, on the tissue antioxidant defense system and lipid peroxidative status ...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480540903203984
更新日期:2010-04-01 00:00:00
abstract::It is generally thought that residual unpolymerized (meth)acrylic monomers commonly found in pressure sensitive adhesive tapes for medical use may cause dermal irritation, but a systematic study has never been carried out. Therefore, we assessed the potential dermal irritating effect of residual (meth)acrylic monomers...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.3109/01480540903311043
更新日期:2010-01-01 00:00:00
abstract::In this study, evaluation of the myocardiotoxic effect potential of ciprofloxacin and ofloxacin in juvenile rats and the role of oxidative stress in heart toxicity was conducted. Doses (25 and 50 mg/kg) of each drug were administered to the rats for 1 week. Serum biochemical cardiotoxicity parameters and tissue malond...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480540902882176
更新日期:2009-01-01 00:00:00
abstract::Antioxidant activity of Acacia salicina extracts was determined by the ability of each extract to inhibit lipid peroxidation, to protect against DNA strand scission induced by hydroxyl radicals, and to scavenge the free radical, 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS(*+)). The IC(50) values of t...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480540802593899
更新日期:2009-01-01 00:00:00
abstract::The purpose of this study was to evaluate the effects of bleached kraft mill effluent on selected physiological and hematological endpoints in fingerling largemouth bass (Micropterus salmoides). Fish were exposed for 35 days to surface water collected at sites up- and downstream from a pulp and paper mill treatment-ef...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480540802432643
更新日期:2009-01-01 00:00:00
abstract::The Salmonella typhimurium/microsome assay is a widely used bacterial genotoxicity assay to test potential carcinogens. The aim of this work was to evaluate the mutagenic and antimutagenic activities with and without the addition of an extrinsic metabolic activation system of essential oils obtained from an aerial par...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480540903196790
更新日期:2009-01-01 00:00:00
abstract::The nicotine metabolism of CYP2A6 (CYP2A6*1A,*1B, and *1C), and the cholecystokinin (CCK; which modulates the release of dopamine) and CCK-A receptor gene and personality traits for NEO-FFI, was investigated for the mechanism for elucidation of the smoking behavior in Japanese populations. The frequency of the CYP2A6*...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章,评审
doi:10.1080/01480540903203976
更新日期:2009-01-01 00:00:00
abstract::The objective of the present study was to evaluate the oxidative stress potential of low-level organophosphate fenthion exposure with the modulatory effect of buthionine sulfoximine in the liver of Cyprinus carpio L. The fish were exposed to 20% of 96-hour LC(50) of fenthion for 24 and 96 hours. Total and oxidized glu...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480540802171233
更新日期:2008-01-01 00:00:00
abstract::Acute and repeated oral and dermal rat toxicology studies of standard designs were conducted on four methyl ethyl ketoxime (MEKO) silanes and four methyl isobutyl ketoxime (MIBKO) silanes. Each compound contained either MEKO or MIBKO groups (but not both) and either a single methyl, vinyl, or phenyl group (trifunction...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480540701688766
更新日期:2008-01-01 00:00:00
abstract::A large number of cationic amphiphilic drugs (CADs) are known to cause phospholipidosis (PLD) in vivo. In the present study, we have built upon our previous findings to further qualify the use of a fluorescently labeled phospholipid-based cell-culture assay to detect PLD-inducing drugs. In this paper, we demonstrate t...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480540802391229
更新日期:2008-01-01 00:00:00
abstract::Exposure to aldehydes represents potential risks to human and animal health. Cyclic aldehydes such as benzaldehyde, 2-furaldehyde, and paraldehyde were found to induce formation of stable DNA-protein cross-links (DPXs) in cultured human lymphoma cells. A relationship between increased cytotoxicity and DPX formation wa...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480540601017603
更新日期:2007-01-01 00:00:00
abstract::Three alkyl diamines, which are by-products formed and separated during the production of hexamethylene diamine, have been tested, mostly for their acute toxicity. This paper reviews methodologies used and the results obtained from these three chemicals. All three tested [2-methyl-1,5-pentanediamine (2-MP), 1,3-diamin...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480540601186994
更新日期:2007-01-01 00:00:00
abstract::Nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, celecoxib, and etoricoxib are reported to act as chemopreventive agents in experimental colon cancer induced by 1,2-dimethylhydrazine (DMH) as they are known cyclooxygenase (COX) enzyme inhibitors. To determine whether NSAIDs can also effectively modulate ...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480540701522106
更新日期:2007-01-01 00:00:00
abstract::Toxic fungal metabolites - mycotoxins - cause poisonings after consumption of contaminated food commodities. The most probable intoxications are connected with eating poorly stored food or inhaling of moldy dust. One of the effective ways to protect people against mycotoxins is timely detection. Several methods such a...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章,评审
doi:10.1080/01480540701375232
更新日期:2007-01-01 00:00:00
abstract::In our previous reports, aspirin, an antipyretic analgesic, suppressed the genotoxicity of mitomycin C (MMC) in a somatic mutation and recombination test (SMART) in Drosophila melanogaster. In order to reveal the mechanism of the anti-genotoxicity of aspirin, we evaluated the suppressing ability of each aspirin metabo...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480540600820528
更新日期:2006-01-01 00:00:00
abstract::Ammonium perfluoroocanoate (APFO) was repeatedly administered orally to male Crj:CD(SD)IGS rats for 14 days. Doses of APFO were 0, 0.5, 5, and 50 mg/kg. Significant increases and increasing tendencies in absolute/relative weight of the liver and no change in weight of the spleen were observed in all groups. Although i...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480540600653143
更新日期:2006-01-01 00:00:00
abstract::The genotoxic effect of CBZ has been investigated in few studies. There is little evidence linking carbamazepine (CBZ) with any genotoxic effects, particularly in vitro micronucleus test using cytogenesis-block technique. In this study, the genotoxicity of the antiepileptic drug, carbamazepine, was tested using cytoki...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480540600566832
更新日期:2006-01-01 00:00:00
abstract::Effects of diazinon, at different concentrations and exposure times, were investigated in freshwater fish, Cyprinus carpio, to elucidate the possible mode of action on lipid peroxidation together with the inhibitory effect of diazinon on acetylcholinesterase activity and changes in tissue protein levels. Cholinesteras...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480540500408622
更新日期:2006-01-01 00:00:00
abstract::The status of brain antioxidant enzymes and glutathione in methacrylonitrile (MeAN)-intoxicated Wistar rats was correlated with the levels of lipid peroxidation products. Optimum changes were observed 30 min and 60 min after oral administration of MeAN at dosages of 50 mg/kg body weight per day (0.25 LD50) and 100 mg/...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1081/dct-52536
更新日期:2005-01-01 00:00:00
abstract::Short-term lymphocyte cultures from human peripheral blood samples were incubated with various aliquots of the carbofuran pesticide. After 48 h of initiation and 24 h of exposure to the carbofuran pesticide aliquots, it was seen that carbofuran caused an increase in the frequency of chromosomal aberrations, and the in...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1081/dct-200064508
更新日期:2005-01-01 00:00:00
abstract::Phospholipidosis is the excessive accumulation of intracellular phospholipids in cell lysosomes. Drugs that induce this disease often share common physiochemical properties and are collectively classified as cationic amphiphilic drugs (CADs). Although the cause of phospholipidosis and morphologic appearance of affecte...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1081/dct-39743
更新日期:2005-01-01 00:00:00
abstract::The object of this study was to evaluate the toxicity of norbornene fluoroalcohol (NBFOH), which is used as an intermediate in the production of fluorinated monomers and polymers. NBFOH was evaluated for acute oral, dermal, and inhalation toxicity, dermal sensitization using the Local Lymph Node Assay (LLNA), mutagene...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1080/01480540500262680
更新日期:2005-01-01 00:00:00
abstract::Organoselenium compounds can cause anemia in mice, possibly as a consequence of impairment of the heme biosynthesis pathway. Such compounds can inhibit the sulfhydryl-containing enzyme delta-aminolevulinate dehydratase (delta-ALA-D), which is involved in the heme biosynthetic pathway, leading to a decrease in the synt...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1081/dct-200039720
更新日期:2004-11-01 00:00:00
abstract::Studies have demonstrated that benzodiazepine compounds are effective at antagonizing seizure activity produced by the organophosphate (OP) cholinesterase inhibitor soman. In this present study we have investigated the pharmacokinetics of midazolam and its associated effects on electroencephalographic (EEG) activity f...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1081/dct-120030727
更新日期:2004-05-01 00:00:00
abstract::The fluoride reactivation process was evaluated for measuring the level of sarin or soman nerve agents reactivated from substrates in plasma and tissue from in vivo exposed guinea pigs (Cava porcellus), in blood from in vivo exposed rhesus monkeys (Macaca mulatta), and in spiked human plasma and purified human albumin...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1081/dct-120027901
更新日期:2004-02-01 00:00:00
abstract::Cisplatin-induced nephrotoxicity is closely associated with an increase in lipid peroxidation. In several previous reports it was claimed that acetylsalicylic acid (ASA) shows its therapeutic potential as a free radical scavenger. The aim of the study was to investigate effects of ASA on cisplatin induced nephrotoxici...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1081/dct-120024841
更新日期:2003-11-01 00:00:00
abstract::The potential maternal and developmental toxicity of cyclododecatriene (CDDT) was assessed in rats. Groups of 22 time-mated female Crl:CD (SD) BR rats were exposed by inhalation (whole-body, 6 h/day) to either 0 (control), 10, 25, or 67 ppm CDDT over days 6-20 of gestation (days 6-20 G); the day of copulation plug det...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1081/dct-120022649
更新日期:2003-08-01 00:00:00
abstract::This Visual Basic computer program has been developed for drug dosage conversions using metabolically active mass (MAM) of the animals. The two body weights (one with known dosage and the other, for which the dosage has to be calculated) and the known dosage are entered in the respective input boxes and the appropriat...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1081/dct-120017557
更新日期:2003-02-01 00:00:00
abstract::This paper discusses the merits and disadvantages of a specific proposal for a numerical calculation of the reference dose (RfD) with explicit recognition of both uncertainty and variability. It is suggested that the RfD be the lower (more restrictive) value of: The daily dose rate that is expected (with 95% confidenc...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章,评审
doi:10.1081/dct-120014793
更新日期:2002-11-01 00:00:00
abstract::Currently, no standardized and well-validated alternative models exist for screening for progesterone-responsive endocrine disrupting chemicals (EDCs). Because of this, a rapid assay for evaluating progestin/antiprogestin activity using Xenopus oocyte germinal vesicle breakdown (GVBD) as a model was evaluated. Five co...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1081/dct-120005892
更新日期:2002-08-01 00:00:00
abstract::Cyclododecatriene (CDDT, CAS No. 4904-61-4) was administered daily by oral gavage to groups of Crl:CD (SD)IGS BR rats at dose levels of 0 (control), 30, 100, or 300 mg/kg/day. Female rats were dosed for four weeks premating, through mating, gestation, and lactation (a total of 55 to 63 days of treatment). Male rats we...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1081/dct-120003257
更新日期:2002-05-01 00:00:00
abstract::The objective of this study was to determine if single/double strand DNA breaks could be induced by monocrotophos (organophosphorus pesticide) in mice in vivo using the comet assay. Mice were dosed orally with 0.046, 0.093, 0.186, 0.373 and 0.746 mg/kg body weight of monocrotophos, and the assay was performed on whole...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1081/dct-100108472
更新日期:2002-02-01 00:00:00
abstract::Experiments were carried out to ascertain whether or not saffron (dried stigmas of Crocus sativus L.), a commonly used agent for flavoring and coloring food can exert modulatory effects on the in vivo genotoxicity of cisplatin (CIS), cyclophosphamide (CPH), mitomycin C (MMC) and urethane (URE). For this purpose, Swiss...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1081/dct-100106266
更新日期:2001-11-01 00:00:00
abstract::Peroxysomicine A1, a novel potential anticancer compound induced cell death in established cell lines and in a primary culture of rat neonatal cardiomyocytes. Non-transformed cells are less sensitive to the compound than transformed cell lines. Fluorescent microscopy of dying cells stained with DNA-specific dyes revea...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1081/dct-100103725
更新日期:2001-08-01 00:00:00
abstract::The developmental toxicities of five test compounds including carbon tetrachloride, urethane, phenacetin, parathion, and chloroform, were evaluated using Frog Embryo Teratogenesis Assay--Xenopus (FETAX), with minor modification. Post-isolation mixtures of differently-induced rat liver microsomes (phenobarbital- (PB), ...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1081/dct-100102605
更新日期:2001-05-01 00:00:00
abstract:BACKGROUND:Plasmodium yoelii nigeriensis (P. y. nigeriensis) produces lethal malaria infection in Swiss albino mice. Reactive oxygen species (ROS) such as superoxide anion, hydrogen peroxide along with endogenously produced tumor necrosis factor (TNF) have been implicated in the pathogenesis of malaria. OBJECTIVE:Stud...
journal_title:Drug and chemical toxicology
pub_type: 杂志文章
doi:10.1081/dct-100101976
更新日期:2000-11-01 00:00:00